WPT details: https://wpt.fyi/results/fetch/api/request/request-bad-port.any.html?label=experimental&label=master&aligned
Connections to HTTP, HTTPS or FTP servers on port 10080 will fail. This is a mitigation for the NAT Slipstream 2.0 attack. It helps developers by keeping the web platform safe for users.
Mitigation for the NAT Slipstreaming attack: https://samy.pl/slipstream/. Preserves user confidence in the web by preventing their browser being used as a vector to attack their internal network.